Project Sicario Merger (PSM) is an experimental new way of building and merging mods for Project Wingman: now available locally on your PC. PSM can build a merged mod on your machine from presets, Sicario patches, PSM-compatible skin mods and even other merged mods, all with less compatibility issues and less downloads required.
For more info on Project Sicario Merger (PSM) itself, check out the mod page for Project Sicario Merger, or the Introduction and Getting Started on Project Sicario itself.
Vortex (with WingVortex 0.2.1+) has integrated support for merging mods with PSM. Just install PSM from Nexus Mods like any other mod, enable it on the Mods page and then turn on the PSM integration in Settings > Interface. Vortex will automatically run PSM after each deploy and manage your merged mod like any other mod in your mods list.